Agrigento can be a challenge for travelers relying on walking alone. While the historic city center is charming and best explored on foot, offering a delightful walking experience through its narrow streets, the compactness doesn't extend beyond these areas. Essential destinations such as the Valley of the Temples are located outside the central city and require additional transportation. Despite its picturesque appeal, the infrastructure may not fully support a walker's daily needs as many modern conveniences aren't easily accessible on foot.

Public transportation in Agrigento exists but isn't extensive. The city offers bus services that connect major tourist spots like the Valley of the Temples to the city center, which can be a convenient option for travelers. However, the frequency and coverage might struggle to meet the needs of someone requiring consistent citywide transit options. The train station provides connections to major cities like Palermo and Catania, though within Agrigento itself, the limited scope may necessitate alternate means of transport for daily activities.

The hilly terrain of Agrigento poses challenges for cyclists, and the lack of dedicated bike paths further complicates matters. Bicycling is certainly possible, but not without its difficulties, making it more feasible for leisure rides rather than practical daily commuting. Travelers seeking to use a bike for getting around the city might find navigating the steep streets and limited infrastructure to be cumbersome.