Amherst offers a range of walkability depending on your location within the town. Areas such as Williamsville present more pedestrian-friendly environments with a concentration of shops, cafes, and restaurants, while other regions, like East Amherst, are much more car-dependent. For travelers, this means that staying in select neighborhoods could allow for some errands to be accomplished on foot, although a car might be necessary for comprehensive mobility throughout the town.

Amherst's public transit system is primarily managed by the Niagara Frontier Transportation Authority (NFTA), with several bus routes providing connections to Buffalo and surrounding areas. However, the frequency and coverage are limited, which may introduce challenges for travelers relying on buses to reach co-working spaces, meetings, and attractions. While it's possible to navigate via public transit, it requires strategic planning and may not serve all needs efficiently.

Amherst offers some dedicated bike paths such as the Amherst Canalway Trail and Ellicott Creek Trailway, which provide recreational biking opportunities. However, these paths don't fully cover the town, and cyclists often encounter heavy traffic and disconnected routes. The flat terrain does aid in making biking an attractive option for some routes, but travelers need to be cautious about traffic safety and route planning when relying on bikes for daily errands or commuting.