Ancona's city center is compact and easily navigable on foot, making it convenient for travelers to explore attractions, dine, and shop without needing a vehicle. Despite the city's hilly terrain, which can be challenging, staying within the central district allows for a pleasant walking experience. However, walkability decreases further from the center, where public transport or a personal vehicle becomes necessary.

Ancona offers a reliable bus and trolleybus network that connects key parts of the city, making it convenient for travelers to reach various destinations, including the airport and train station. While the system isn't as comprehensive as in larger cities, it provides adequate coverage for getting around, though users might need to plan ahead and expect some waiting times.

Ancona's bikeability is restricted by its hilly landscape and busy traffic, limiting its practicality for daily commuting or errands. While there are some bike paths, including along the coast, and the city is part of the Adriatic Ciclovia, the terrain may be challenging for carrying equipment or navigating routinely. Recreational cycling is an option, particularly on flatter coastal routes, but using a bike for everyday transport is less ideal.