Antofagasta offers a reasonable level of walkability, particularly in its compact downtown area close to the coast. The city is laid out in a grid pattern, facilitating pedestrian movement, especially around central regions where cafes, restaurants, and shops are densely packed. Additionally, pedestrian axes make walking more enjoyable in key areas. However, some peripheral neighborhoods might not be as walkable, requiring longer journeys or alternate transport options for errands and activities outside the main zones.

Public transit in Antofagasta primarily relies on buses, taxis, and 'colectivos,' which are shared taxis. The bus service, TransAntofagasta, covers extensive areas of the city and is well-supported by digital tools like the Moovit app, offering real-time route information. Though there's no metro or tram, the bus system provides sufficient accessibility around major destinations. For a traveler, using taxis and 'colectivos' offers a flexible option for navigating the city, though long-term improvements could enhance overall coverage and convenience.

Although Antofagasta has a generally flat terrain that is theoretically conducive to biking, the city currently lacks extensive dedicated cycling infrastructure. Plans exist to expand bicycle lanes and integrate a public bike system, but current traffic conditions may make cycling less safe and comfortable in certain areas. Travelers might consider biking for leisure or short commutes on established bike paths, keeping in mind that it may not yet serve as a reliable daily transport method.