Argostoli is an exceptionally walkable town thanks to its compact size, flat terrain, and the centralized location of key amenities like shops, cafes, and restaurants. Much of the town's central area is pedestrian-friendly, making it easy for travelers to navigate without the need for a car. With accommodation options near essential services, walking in Argostoli is both convenient and enjoyable for travelers.

While Argostoli functions as the central transport hub of Kefalonia with bus routes connecting to other parts of the island, the infrequency and limited reach of public transit can be a drawback, especially for accessing remote areas. The local ferry to Lixouri offers an alternative to driving, but overall, travelers may find the public transport system less accommodating for spontaneous explorations.

Cycling in Argostoli is feasible, particularly with rental bikes available and suitable paths like those along the Koutavos Lagoon. However, the mixed condition of roads and limited dedicated bike lanes, combined with hilly terrain, can make cycling challenging. For short trips in the town, biking is practical, but travelers may need to combine biking with other modes of transport for broader island exploration.