Ascoli Piceno's historic center offers an ideal setting for walking, with a compact and flat layout full of pedestrian-friendly areas. Everything a traveler might need daily is within walking distance, from cafes and grocery stores to coworking spaces and gyms. The ease of navigation and the density of services means less time commuting and more time enjoying what the city has to offer on foot.

While not the most extensive, Ascoli Piceno provides sufficient public transport options suitable for a traveler's needs. Buses connect the city to major destinations like Rome and regional stops are within easy walking distance of the city center. Train services further facilitate exploration beyond Ascoli Piceno, although availability within the city and nearby regions might be limited compared to larger urban areas.

Cycling in Ascoli Piceno is quite feasible due to the flat terrain of the city center, although dedicated cycling lanes are limited. The Biciplan indicates efforts towards improving bikeability, making it a practical option for exploring the city and running errands. Enthusiastic cyclists might find the hilly areas outside the center excellent for recreational rides, though these can be more demanding for daily bike commuting.