Atotonilco el Alto offers a reasonably walkable environment, particularly in its central area around the Plaza Principal and Parroquia de San Miguel Arcángel. This part of town is lined with shops, restaurants, and essential services, making it convenient for travelers to explore on foot. However, as the town expands outward, the dependency on some form of transport becomes necessary for daily errands. Additionally, travelers should be cautious and mindful of safety concerns when walking, especially outside of daylight hours.

Public transportation in Atotonilco el Alto is primarily limited to buses and taxis, with the bus station centrally located. This setup provides a basic level of convenience for local transport, but the options may not be extensive enough to meet the diverse transit needs of a traveler. Connection to nearby cities such as Guadalajara can be time-intensive if reliant solely on public transit, suggesting that the use of a personal vehicle or ride-sharing services might be more effective for longer journeys.

Atotonilco el Alto doesn't have substantial biking infrastructure, which limits bikeability. The absence of dedicated bike lanes and the hilly terrain around the area can make cycling challenging and less practical as a primary means of transportation. While short bike trips within the central area may be manageable, cyclists should be prepared for uneven and potentially difficult terrains, suggesting biking may be better suited for recreational use.