Greenville's walkability is reasonable but not outstanding. The downtown area offers a vibrant and walkable environment with plenty of amenities like restaurants, coffee shops, and coworking spaces accessible by foot. Additionally, the Greenville Greenway provides a pleasant walking route for those who enjoy a scenic stroll. However, as one moves away from downtown, the city becomes more car-dependent, with inconsistent sidewalk coverage and amenities spread out across larger distances. This mixed infrastructure suggests that while some key areas support walking, a vehicle may still be necessary for full convenience and access to various parts of the city.

Public transportation in Greenville is quite limited, making it challenging for travelers seeking a car-free lifestyle. The Greenville Area Transit (GREAT) Bus System does operate within the city, but coverage is far from comprehensive and service hours are restricted to weekdays with no weekend service. Most routes end relatively early in the evening, restricting mobility. The G.K. Butterfield Transportation Center serves as a transportation hub, yet the availability and convenience of public transit are not conducive to flexible travel needs, leading travelers to often rely on cars or rideshare services for broader exploration.

Greenville offers moderate bikeability with ongoing improvements to its bike network. The presence of the Greenville Greenway provides an excellent dedicated path for bicyclists, and some streets feature bike lanes to facilitate cycling. However, cyclists often share the road with vehicular traffic, and bike-specific infrastructure is not consistent throughout the city. The generally flat terrain is advantageous for cycling, yet safety concerns arise where bike lanes are lacking and traffic is heavier. While biking can be a practical choice for short journeys and leisure activities, it may not fully replace the need for other transport options in daily commuting.