Greenville's walkability is concentrated mainly in its downtown area, where travelers can comfortably explore shops, restaurants, and attractions such as Falls Park on the Reedy on foot. However, outside of this core area, the city becomes more car-dependent, making it less convenient to reach other parts of the city or essential services without a vehicle. For travelers, staying in the downtown area is ideal to enjoy a walkable lifestyle, though other forms of transportation will be needed to fully experience Greenville.

Public transportation in Greenville is fairly limited, with a bus system operated by Greenlink that has coverage issues and may not have the frequency or reach ideal for exploring the city extensively without a car. While some key areas connect through this system, it may not be convenient for all destinations or travel schedules. The free downtown trolley offers a pleasant service but is restricted in its route and hours, limiting usefulness for a traveler looking to navigate the city efficiently.

Greenville is becoming more bike-friendly, with significant infrastructure like the Prisma Health Swamp Rabbit Trail providing a protected route for cyclists. The city's efforts to expand bike lanes and the presence of a bike-share program make downtown and popular neighborhoods more accessible by bike. However, the inconsistency in bike lane availability and unpredictability of traffic can make biking challenging and less inviting beyond certain areas. For travelers, biking provides a great way to explore the downtown and trails but might not be suitable for every situation in the city.