Guadalupe, Nuevo Leon, offers a highly walkable environment for travelers, especially in areas close to the city center. The urban layout is compact, allowing travelers to easily reach a diverse range of shops, restaurants, and essential services on foot. This setup significantly reduces the need for a car, making it convenient to actively explore the city and accomplish daily errands. While footpaths and crossings could occasionally be inconsistent, the general accessibility remains advantageous for walkers.

Public transport in Guadalupe is fairly accessible, with the presence of the Metrorrey system and various bus routes connecting it to Monterrey and other nearby areas. These options facilitate convenient travel between Guadalupe and key attractions, workspaces, and amenities. Although the coverage and frequency of public transport might not extend to every neighborhood, these transport modes are generally reliable for reaching major destinations. However, travelers should be prepared for potential peak-time crowding and minor schedule variations.

Guadalupe provides moderate bikeability, offering some infrastructure such as bike paths in specific areas. While comprehensive biking lanes may not be uniformly available across the city, and terrains can vary, cycling remains a viable means for short distances or leisure rides. Travelers should exercise caution, as they may frequently encounter mixed traffic conditions. Despite these challenges, biking is a feasible alternative for those willing to navigate the shared spaces with other vehicles.