Gualdo Tadino's central area, Centro Storico, is particularly conducive to walking. It boasts a compact layout, with a variety of local shops, cafes, and daily needs within easy reach. The historic charm of the town makes walking pleasant, though the mountainous and hilly terrain surrounding the central area can pose challenges for those on foot further out from the center. Overall, for travelers staying in the heart of the town, most errands can be comfortably done on foot.

The town has basic public transport connections, with a train station offering regional trips and several bus lines that connect to nearby places like Assisi. However, the frequency and reach of these services may be limited, requiring careful planning from travelers who need to rely on public transport. While practical for regional travel, using public transit within Gualdo Tadino might not be the most convenient, especially outside peak commuting times.

Gualdo Tadino's hilly terrain makes it a challenging place for casual cyclists, as the town lacks noticeable bike infrastructure for regular commuting. While the area surrounding the town is renowned for mountain biking routes appealing to avid cyclists, these are not necessarily suited for daily transportation needs. This makes biking a less feasible option for everyday travel within the town, aside from recreational purposes.