Guelph offers a pedestrian-friendly environment in its downtown area, where travelers can find a lively mix of restaurants, shops, and social spots within walking distance. While many parks are close by, the need to walk further for certain amenities may push travelers to rely on other modes of transportation if staying outside the central area. This makes Guelph moderately walkable, particularly when venturing beyond the heart of the city, where access can require public transit or a car.

Public transportation in Guelph is well-organized, with a network of buses that cover the entire city. The Guelph Central Station provides convenient connections to regional and national rail services, which is advantageous for travelers looking to explore beyond the city limits. The presence of the UPass for students is a highlight, although the variability in bus service schedules may require some planning on off-peak times or holidays.

Cycling in Guelph is a convenient option thanks to its robust infrastructure, which includes bike lanes, paths, and trails. The city's commitment to enhancing bike-friendliness through continued development of cycling routes and facilities makes it an excellent option for those who prefer to navigate the city on two wheels. The accessible off-road trails and quiet country roads offer added benefits for both casual biking and commuter cycling.