While Hermosillo offers certain walkable areas like the small, amenity-rich Palo Verde neighborhood, it is primarily designed with vehicular travel in mind, resembling many American-style cities. Travelers might find themselves in need of a car to conveniently access various parts of the city, as not all destinations are easily reachable on foot. The city remains somewhat walkable with certain key amenities accessible, but extensive walking for daily errands may prove challenging.

Public transit in Hermosillo is not highly developed, with more limited options that might not cover the whole city efficiently. The available bus services and ride-sharing apps like Uber fulfill some needs, but they lack the convenience and reliability that digital nomads might seek for seamless local travel. Travelers often find that alternate transportation modes are necessary for reaching diverse locations efficiently, factoring in the less frequent and extensive public transit services.

Hermosillo has some bike-friendly areas like Madero Park and La Ruina Park, with growing initiatives such as "Biciclando" aiming to enhance cycling infrastructure. Nevertheless, the presence of traffic and a hot climate can deter cyclists. While pleasant biking paths exist, it is not always ideal as a primary method for running errands or commuting across the city, though biking remains a viable option for leisure and in select suitable neighborhoods.