Iquique is a particularly walkable destination, especially in its central areas. The city benefits from a charming waterfront promenade, known as the "malecon," which doubles as a leisurely walkway and extends into a bike path. Within the historic district of Baquedano, travelers can enjoy pedestrian-only streets amidst unique colonial architecture. The city's grid-like street layout further enhances easy navigation, with many cafes, restaurants, shops, and other amenities conveniently located near popular locales like the beach and main plazas. While some industrial or less safe areas exist, they are mostly on the outskirts and not a concern for the typical traveler staying in central zones.

Public transportation in Iquique consists mainly of buses, known as "micros," which provide coverage along major routes across the city. These buses run frequently and are budget-friendly, making them a practical option for most travelers. Although a metro or tram system is absent, the bus network connects essential locations such as the Zofri duty-free zone and other key neighborhoods. Apps like Moovit can assist in navigation. While generally sufficient for traveling around, the system is not as extensive as those found in larger cities, and taxis are a more immediate but costlier alternative.

Biking in Iquique can be a pleasant experience, largely due to the dedicated bike path along the scenic waterfront. The coastal areas are relatively flat, which aids in making biking more accessible for leisure and short commutes. However, the city's overall biking infrastructure is limited and mainly concentrated near the coast, with fewer bike lanes throughout the city. While the terrain includes some hilly sections, traffic and the scattered presence of bike paths can make biking less feasible for everyday commuting. Nonetheless, bike tours are available, showcasing the city's potential for cycling as a form of exploration.