Isiolo's layout and infrastructure make it a less walkable city for travelers. The town is spread out, leading to a reliance on vehicles to access amenities and different parts of the city. While the town center might offer some facilities within walking distance, the overall convenience and safety, especially at night, are limited. The presence of a large market provides a focal point for foot traffic, but isolated neighborhoods require other means of transportation.

Public transportation in Isiolo includes buses and matatus, which serve as the primary means of travel for locals and travelers alike. While Isiolo functions as a transit hub to northern regions, the service frequency and coverage can be insufficient for travelers needing dependable transit options. The limited reliability may pose challenges for timely arrivals at work locations or during leisure excursions.

Biking in Isiolo is not commonly supported by the city's infrastructure. The presence of paved roads towards Moyale offers some cycling potential, but the lack of dedicated bike lanes and challenging terrain with hills can deter cyclists. Additionally, noted safety concerns and possibly aggressive traffic might dissuade travelers from relying on cycling as a main form of daily commute.