Iskenderun's central areas are notably walkable, with easy access to shops, restaurants, and cafes catering to travelers' daily needs. The layout of the town ensures that many essential services are within walking distance, fostering a pedestrian-friendly environment ideal for exploring local culture. However, beyond the very central areas, travelers may require taxis to reach locations like the bus station, suggesting a reliance on additional transport for longer journeys.

Public transit in Iskenderun poses challenges for travelers, especially those unfamiliar with Turkish. While city buses are available, the lack of clear, user-friendly route information makes navigation difficult for non-Turkish speakers. The absence of dolmuşes (shared taxis) limits transport flexibility, leading travelers to depend more frequently on taxis or private vehicles. Consequently, public transit may not be the most convenient choice for efficiently traversing the city.

Cycling in Iskenderun offers both opportunities and challenges. The presence of what is reportedly the longest uninterrupted bike lane in Turkey along the scenic coastal route bodes well for leisurely rides. However, inconsistent cycling infrastructure elsewhere in the city and mixed terrain can hinder practicality for daily utility biking. While travelers may enjoy recreational biking along the coast, the cycling network might not fully support everyday errands within the urban core.